Acne scars: Lipogems and CO2 laser, the results of a study by Image Regenerative Clinic
Innovazione e Ricerca

Acne scars: Lipogems and CO2 laser, the results of a study by Image Regenerative Clinic

The use of Lipogems micro fragmented adipose tissue in regenerative medicine, associated with flat dermoabrasion and ablative CO2 laser, represents a valid strategy not only in terms of clinical efficacy, but also of safety and skin improvement in the treatment of acne scars.

In addition, the use of Lipogems, in a study conducted by experts at Image Regenerative Clinic and published in Modern Research in Plastic and Reconstructive Surgery, has been shown to reduce post-treatment side effects (edema, inflammation, pain, dry skin) with a much faster return to normal daily activities and greater patient satisfaction.

Acne Statistics

Acne is a common condition affecting about 70-80% of the general population. In about 10-15% of cases, acne leaves acne scars that have a significant impact on people’s quality of life. It is a condition that mainly affects adolescents (juvenile acne), but it is common in adults either.

The Study

Currently, there is no single treatment that can guarantee satisfactory results in the treatment of permanent scars; however, the use of multiple therapeutic modalities in combination (multimodal therapy) has been shown to have a synergistic effect and satisfactory results. Based on the premise of combining different treatments in the remodeling of acne scars, the study performed by Image Regenerative Clinic, which has involved 15 patients treated with 3 different techniques, was led by Prof. Carlo Tremolada, scientific director of Image Regenerative Clinic, and involved Dr. Alice Miegge and Dr. Laura Loda, surgeons at Image Regenerative Clinic.

«In our experience, surgical dermabrasion, infiltration of micro fragmented autologous adipose tissue and fractional CO2 laser treatment in deep resurfacing mode have proven to be complementary – explains Professor Carlo Tremolada. – Surgical dermabrasion of the subcutaneous plane under the acne scar allowed the tissue to be freed from the adhesions responsible for the scar and to prepare the tissue for infiltration with Lipogems micro fragmented adipose tissue. The treatment with Lipogems, through the action of stem cells and derived secretion factors, has stimulated the synthesis of collagen, neoangiogenesis and increased the productivity and migration of fibroblasts, which are necessary to regenerate the skin. Finally, treatment with fractional CO2 laser with deep resurfacing has allowed the synthesis of new collagen to be induced through the activation of dermal fibroblasts or growth factors».


Patients aged between 19 and 54 years, of whom 12 women and 3 men, were reevaluated at 3, 6, 9 and 12 months after treatment: the effectiveness of scar improvement was assessed based on an ECCA score (échelle d’évaluation clinique des cicatrices d’acné) and subjective patient satisfaction through the IGA scale (Investigator’s Global Assessment). The results demonstrate a remarkable objective and subjective improvement: patients also reported a reduction in treated scars and an improvement in pores and skin roughness.


The combination of surgical dermoabrasion, Lipogems infiltration, and CO2 fractional laser treatment represents a promising and effective strategy for the treatment of acne scars, leading to significant improvement in both objective and subjective parameters, with a favorable safety profile.